Protein Sequence Variant Design Suite
Create multiple mutations and variations of selected base proteins instantly, using advanced class-directed and interactivity-directed analysis.
How ProteinWriter Works
A streamlined pipeline built for fast screening and variant optimization — in three simple steps.
Choose your variance level
Select low variance (LVAR), moderate variance (MVAR) or high variance (HVAR) — or combine them — depending on your experimental thresholds.
Choose your base protein
Pick the structural baseline for your design from our directory of base proteins, spanning eight organism categories from bacteria to human.
Design your variant protein
Generate your variant sequences and download them, ready to take to the bench.
Transparent per-amino-acid pricing
You pay for the length of your sequence and the variance you ask for — no platform fees, no subscriptions. Rates are additive, so combining levels combines their coverage.
Low Variance (LVAR)
$0.09
per amino acid
High-precision, single-digit substitutions to fine-tune protein properties and secure lower folding and compatibility risks.
- Single-digit substitutions against the base protein
- Lowest folding and compatibility risk
- Downloadable variant sequences (FASTA)
Moderate Variance (MVAR)
$0.08
per amino acid
Critical sites optimization with coordinated modifications of 1% of base protein.
- Coordinated modification of ~1% of the base protein
- Critical functional site optimization
- Downloadable variant sequences (FASTA)
High Variance (HVAR)
$0.07
per amino acid
Targeted region exploration to unlock complex traits while maintaining >97% sequence preservation.
- Targeted regional exploration
- Greater than 97% sequence preservation
- Downloadable variant sequences (FASTA)
Ready to start designing?
Create your free account to access our advanced protein sequence design tools.
Create Free Account